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The Role of Hypoxia and Cancer Stem Cells in Development of Glioblastoma

4 May 2023

Abstract excerpt

Glioblastoma multiform (GBM) is recognized as the most malignant brain tumor with a high level of hypoxia, containing a small population of glioblastoma stem like cells (GSCs). These GSCs have the capacity of self-renewal, proliferation, invasion and recapitulating the parent tumor, and are major causes of radio-and chemoresistance of GBM. Upregulated expression of hypoxia inducible factors (HIFs) in hypoxia...

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PMID: 37174078
DOI: 10.3390/cancers15092613

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