Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

1 Feb 2019

Abstract excerpt

Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for the development of the resistant phenotype of GBM under hypoxic conditions remain unclear. To analyze the key pathways promoting therapy resistance in hypoxic GBM, we utilized the U87-MG cell line as a human GBM cell model and the human brain HEB cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Glioma Diagnosis and Treatment
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30775317
DOI: 10.3389/fonc.2019.00033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic GlioblastomaPMID 30775317Read ↗

Stress Response Leading to Resistance in Glioblastoma—The Need for Innovative Radiotherapy (iRT) ConceptsSemantic proximity Read ↗

Comprehensive analysis and experiment of hypoxia and EMT-related genes in prognosis and immune response of glioblastomaSemantic proximity Read ↗

Molecular Characterization of AEBP1 at Transcriptional Level in GliomaSemantic proximity Read ↗

Research progress of drug resistance mechanism of temozolomide in the treatment of glioblastomaSemantic proximity Read ↗

Elucidation of the effects of hypoxia on DNA repair machinery in brain tumour cellsSemantic proximity Read ↗

Integrated analysis identified core signal pathways and hypoxic characteristics of human glioblastomaSemantic proximity Read ↗

Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma modelSemantic proximity Read ↗

Glioblastoma Stem Cells as a New Therapeutic Target for GlioblastomaSemantic proximity Read ↗

Advances in epigenetic glioblastoma therapySemantic proximity Read ↗

Expression of TMEM59L associated with radiosensitive in glioblastomaSemantic proximity Read ↗

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplaySemantic proximity Read ↗

DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.