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DNA repair mechanisms and their clinical impact in glioblastoma

27 Jun 2016

Abstract excerpt

Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in great part to the action of DNA repair mechanisms that drive resistance and tumor relapse. Understanding the molecular details of these mechanisms and identifying potential pharmacological targets have emerged as vital tasks to improve...

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Identifiers

PMID: 27543314
DOI: 10.1016/j.mrrev.2016.05.005

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