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Article

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.

Cancer treatment reviews - 1 Aug 2003

Shannon Aoife M, Bouchier-Hayes David J, Condron Claire M, Toomey Deirdre

Abstract excerpt

Tissue hypoxia occurs where there is an imbalance between oxygen supply and consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of oxygen, due to exponential cellular proliferation and an inefficient vascular supply. It is an adverse prognostic indicator in cancer as it is associated with tumour progression and resistance to therapy. The expression of several genes controlling tumour...

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PMID: 12927570
DOI: 10.1016/s0305-7372(03)00003-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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