Article

Mirror-image Streptavidin with Specific Binding to “Non-natural” L-biotin

2022-02-03

Abstract excerpt

The streptavidin-biotin system is known to have a very high affinity and specificity and is widely used in biochemical immunoassays and diagnostics. However, this method is affected by endogenous D-biotin in serum sample measurements (biotin interference). While several efforts using alternative high-affinity binding systems (e.g., genetically modified streptavidin and biotin derivatives) have been attempted, thes...

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Literature Corpus work: f8d3a3eb-3ad6-5588-883f-6f395e469ae2
DOI: 10.21203/rs.3.rs-1314454/v1

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