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Engineered streptavidin monomer and dimer with improved stability and function.

Biochemistry - 11 Oct 2011

Lim Kok Hong, Huang Heng, Pralle Arnd, Park Sheldon

Abstract excerpt

Although streptavidin's high affinity for biotin has made it a widely used and studied binding protein and labeling tool, its tetrameric structure may interfere with some assays. A streptavidin mutant with a simpler quaternary structure would demonstrate a molecular-level understanding of its structural organization and lead to the development of a novel molecular reagent. However, modulating the tetrameric...

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Identifiers

PMID: 21892837
DOI: 10.1021/bi2010366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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