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Article

Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors

28 Sept 2009

Abstract excerpt

Adenovirus (Ad)-based vectors offer several benefits showing their potential for use in a variety of vaccine applications. Recombinant Ad-based vaccines possess potent immunogenic potential, capable of generating humoral and cellular immune responses to a variety of pathogen-specific antigens expressed by the vectors. Ad5 vectors can be readily produced, allowing for usage in thousands of clinical trial subjects....

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PMID: 19780714
DOI: 10.1517/14712590903307388

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