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Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2

10 Aug 2022

Abstract excerpt

Adenovirus vector vaccines have been widely and successfully deployed in response to coronavirus disease 2019 (COVID-19). However, despite inducing potent T cell immunity, improvement of vaccine-specific antibody responses upon homologous boosting is modest compared with other technologies. Here, we describe a system enabling modular decoration of adenovirus capsid surfaces with antigens and demonstrate potent...

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PMID: 35949171
DOI: 10.1016/j.ymthe.2022.08.002

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