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Hepatitis B virus enhancer 1 activates preS1 and preS2 promoters of integrated HBV DNA impairing HBsAg secretion

13 Jun 2024

Abstract excerpt

Background & Aims The expression of HBsAg from integrated HBV DNA limits the achievement of functional cure for chronic hepatitis B. Thus, characterizing the unique expression and secretion of HBsAg derived from integrated HBV DNA is of clinical significance. Methods A total of 563 treatment-naïve patients and 62 functionally cured patients were enrolled, HBsAg and HBcAg immunohistochemistry of their liver biopsy...

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PMID: 39253701
DOI: 10.1016/j.jhepr.2024.101144

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