Article

A stable subgenomic reporter coronavirus enables transcriptional profiling of bystander cells

2026-03-03

Abstract excerpt

Insertion of fluorescent reporter genes into viral genomes is a powerful tool for monitoring infection. In coronaviruses, this is commonly achieved by replacing accessory open reading frames, thereby deleting endogenous gene functions. An alternative strategy is to manipulate viral RNA synthesis by inserting copies of the viral transcription regulatory sequence (TRS) which drive the transcription of viral subgenom...

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Literature Corpus work: f8bc8df9-4d92-59fa-ab30-1380e683cda4
DOI: 10.64898/2026.02.27.708290

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