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A nano-luciferase expressing human coronavirus OC43 for countermeasure development

5 Dec 2023

Abstract excerpt

The genetic diversity of the coronavirus (CoV) family poses a significant challenge for drug discovery and development. Traditional antiviral drugs often target specific viral proteins from specific viruses which limits their use, especially against novel emerging viruses. Antivirals with broad-spectrum activity overcome this limitation by targeting highly conserved regions or catalytic domains within viral...

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PMID: 38016504
DOI: 10.1016/j.virusres.2023.199286

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