High-Throughput Single-Cell Kinetics of Virus Infections in the Presence of Defective Interfering Particles

Abstract excerpt

UNLABELLED: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth. In coinfections with helper virus, the diversion of viral proteins to the replication and packaging of DIP genomes can interfere with virus production. Mounting cases of DIPs and DIP-like genomes in clinical and natural isolates, as well as growing interest in DIP-based therapies, underscore a need to better...