Article

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding

2012-07-18

Abstract excerpt

The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E-BP1 on amino acids Thr37 and/or Thr46 represents a rapamycin-insensitive activity of mTORC1. Despite numerous previous reports utilizing serine (Ser)-to-alanine (A...

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Literature Corpus work: f89bb0a0-aee4-537e-94d9-5b87f9edbfb2
DOI: 10.12688/f1000research.1-4.v1

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