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Article

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.

Molecular and cellular biology - 1 Nov 2002

McMahon Lloyd P, Choi Kin M, Lin Tai-An, Abraham Robert T, Lawrence John C

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a Ser/Thr (S/T) protein kinase, which controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates. Both (S/T)P sites, such as Thr36, Thr45, and Thr69 in PHAS-I and the h(S/T)h site (where h is a hydrophobic amino...

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Identifiers

PMID: 12370290
DOI: 10.1128/MCB.22.21.7428-7438.2002
PMCID: PMC135667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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