Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1

2 Apr 2008

Abstract excerpt

Mammalian target of rapamycin complex 1 (mTORC1) phosphorylates proteins such as eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and the S6 kinases. These substrates contain short sequences, termed TOR signalling (TOS) motifs, which interact with the mTORC1 component raptor. Phosphorylation of 4E-BP1 requires an additional feature, termed the RAIP motif (Arg-Ala-Ile-Pro). We have analysed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to PI3K/AKT/mTOR signaling in cancer
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18384376
DOI: 10.1111/j.1742-4658.2008.06372.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1PMID 18384376Read ↗

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.Semantic proximity Read ↗

Identification of a conserved motif required for mTOR signaling.Semantic proximity Read ↗

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.Semantic proximity Read ↗

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 bindingSemantic proximity Read ↗

Molecular details of the Raptor-binding motif on Arabidopsis S6 kinase.Semantic proximity Read ↗

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.Semantic proximity Read ↗

Mammalian Target of Rapamycin (mTOR) Signalling Pathway-A Potential Target for Cancer Intervention: A Short OverviewSemantic proximity Read ↗

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.Semantic proximity Read ↗

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.Semantic proximity Read ↗

Asc1p/RACK1 Connects Ribosomes to Eukaryotic Phosphosignaling.Semantic proximity Read ↗

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.Semantic proximity Read ↗

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.