Identification of a conserved motif required for mTOR signaling.

doi:10.1016/s0960-9822(02)00762-5

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Article

Identification of a conserved motif required for mTOR signaling.

Current biology : CB - 16 Apr 2002

Schalm Stefanie S, Blenis John

Abstract excerpt

BACKGROUND: The mammalian target of rapamycin (mTOR) controls the translation machinery via activation of S6 kinases 1 and 2 (S6K1/2) and inhibition of the eukaryotic initiation factor 4E (eIF4E) binding proteins 1, 2, and 3 (4E-BP1/2/3). S6K1 and 4E-BP1 are regulated by nutrient-sensing and mitogen-activated pathways. The molecular basis of mTOR regulation of S6K1 and 4E-BP1 remains controversial. RESULTS: We...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Motifs
Amino Acid Sequence
Animals
Carrier Proteins
Cell Cycle Proteins
Cell Line
Conserved Sequence
Enzyme Activation
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphoproteins

Phosphorylation

Phosphothreonine

Protein Kinases

Ribosomal Protein S6 Kinases

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 11967149
DOI: 10.1016/s0960-9822(02)00762-5

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