Article

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor

2022-12-11

Abstract excerpt

Rapamycin is a macrolide antibiotic that functions as an immunosuppressive and anti-cancer agent, and displays robust anti-ageing effects in multiple organisms including humans. Importantly, rapamycin analogs (rapalogs) are of clinical importance against certain cancer types and neurodevelopmental diseases. Although rapamycin is widely perceived as an allosteric inhibitor of mTOR (mechanistic target of rapamycin),...

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Literature Corpus work: 3ce9d1ec-0421-5ac3-87c3-374ee4d8da9b
DOI: 10.1101/2022.12.10.519872

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