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Article

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.

The EMBO journal - 21 Apr 2004

Raught Brian, Peiretti Franck, Gingras Anne-Claude, Livingstone Mark, Shahbazian David, Mayeur Greg L, Polakiewicz Roberto D, Sonenberg Nahum, Hershey John W B

Abstract excerpt

The eucaryotic translation initiation factor 4B (eIF4B) stimulates the helicase activity of the DEAD box protein eIF4A to unwind inhibitory secondary structure in the 5' untranslated region of eucaryotic mRNAs. Here, using phosphopeptide mapping and a phosphospecific antiserum, we identify a serum-responsive eIF4B phosphorylation site, Ser422, located in an RNA-binding region required for eIF4A helicase-promoting...

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Identifiers

PMID: 15071500
DOI: 10.1038/sj.emboj.7600193
PMCID: PMC394247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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