Article

Modulating DNA Polα Enhances Cell Reprogramming Across Species

2024-09-20

Abstract excerpt

As a fundamental biological process, DNA replication ensures the accurate copying of genetic information. However, the impact of this process on cellular plasticity in multicellular organisms remains elusive. Here, we find that reducing the level or activity of a replication component, DNA Polymerase α (Polα), facilitates cell reprogramming in diverse stem cell systems across species. In Drosophila male and femal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f895232f-f3b6-5c27-8691-fda15e8ad30a
DOI: 10.1101/2024.09.19.613993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulating DNA Polα Enhances Cell Reprogramming Across SpeciesDOI 10.1101/2024.09.19.613993Read

Aging-associated changes in transcriptional elongation influence metazoan longevitySemantic proximity Read

Neuronal DNA repair mediates systemic mitochondrial maintenance through acetylcholine signalingSemantic proximity Read

DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.Semantic proximity Read

Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies.Semantic proximity Read

Lifespan extension by preserving proliferative homeostasis in Drosophila.Semantic proximity Read

The killifish germline regulates longevity and somatic repair in a sex-specific mannerSemantic proximity Read

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.Semantic proximity Read

Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.Semantic proximity Read

Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespanSemantic proximity Read

Balancing dynamic tradeoffs drives cellular reprogrammingSemantic proximity Read

Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth.Semantic proximity Read

Germline proliferation and its controlSemantic proximity Read