Article

Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

2022-08-31

Abstract excerpt

<h4>ABSTRACT</h4> The dedifferentiation of somatic cells into a pluripotent state by cellular reprogramming coincides with a reversal of age-associated molecular hallmarks. Although transcription factor induced cellular reprogramming has been shown to ameliorate these aging phenotypes in human cells and extend health and lifespan in mice, translational applications of this approach are still limited. More recentl...

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Literature Corpus work: cffc433d-58e4-5c6c-b855-6c6d3ce56de8
DOI: 10.1101/2022.08.29.505222

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