Article
Cerebral perfusion alterations are associated with clinical phenotypes and biotypes across the psychosis spectrum.
Psychological medicine - 24 Sept 2026
Hoang Dung, Zeng Victor, Sritharan Jothini, Mutsaerts Henk J M M, Petr Jan, Trotti Rebekah, Ivleva Elena, Dai Weiying, Hill Scot, Gershon Elliot, Keedy Sarah, Clementz Brett, Taminga Carol, Pearlson Godfrey, Bolo Nicolas, Keshavan Matcheri, Lizano Paulo
Abstract excerpt
BACKGROUND: Cerebral perfusion abnormalities may contribute to the pathophysiology of psychosis spectrum disorders (PSD), including schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar disorder with psychotic features (BP), yet large-scale investigations remain limited. METHODS: Pseudo-continuous arterial spin labeling scans were acquired from 2412 SZ, 2278 SAD, 158 BP, 401 neurotypical controls (NC)...
Read the complete abstract on PubMedTopics
- Humans
- Psychotic Disorders
- Cerebrovascular Circulation
- Female
- Male