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Article

Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms.

Scientific reports - 27 Aug 2018

Wolff Amy R, Bygrave Alexei M, Sanderson David J, Boyden Edward S, Bannerman David M, Kullmann Dimitri M, Kätzel Dennis

Abstract excerpt

Pathological over-activity of the CA1 subfield of the human anterior hippocampus has been identified as a potential predictive marker for transition from a prodromal state to overt schizophrenia. Psychosis, in turn, is associated with elevated activity in the anterior subiculum, the hippocampal output stage directly activated by CA1. Over-activity in these subfields may represent a useful endophenotype to guide...

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Identifiers

PMID: 30150758
DOI: 10.1038/s41598-018-31163-5
PMCID: PMC6110795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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