Article

Flux, toxicity and protein expression costs shape genetic interaction in a metabolic pathway

2018-07-04

Abstract excerpt

Our ability to predict the impact of mutations on traits relevant for disease and evolution remains severely limited by the dependence of their effects on the genetic background and environment. Even when molecular interactions between genes are known, it is unclear how these translate to organism-level interactions between alleles. We therefore characterized the interplay of genetic and environmental dependencies...

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Literature Corpus work: f87ecdde-f3f1-552c-8309-20b79bc5b20e
DOI: 10.1101/362327

Open publication

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