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Environment-by-Environment Interactions Differ Across Genetic Backgrounds.

Molecular biology and evolution - 29 Oct 2025

Schmidlin Kara, Ogbunugafor Brandon C, Sastokas Alexander, Geiler-Samerotte Kerry

Abstract excerpt

Environmental conditions shape phenotype and fitness, influencing which mutations rise in frequency, the maintenance of genetic diversity, and evolutionary outcomes. When the combined impact of two environments deviates from expectations based on their individual effects, this is known as an environment-by-environment interaction. While the terms "gene-by-gene interaction" and "gene-by-environment interaction"...

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Antifungal Agents
Drug Resistance, Fungal
Environment
Gene-Environment Interaction
Genetic Background

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

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PMID: 41206453
DOI: 10.1093/molbev/msaf287
PMCID: PMC12631786

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