Article
Metabolic flux correlations, genetic interactions, and disease.
Journal of computational biology : a journal of computational molecular cell biology - 1 Feb 2009
Veeramani Balaji, Bader Joel S
Abstract excerpt
Many diseases are caused by failures of metabolic enzymes. These enzymes exist in the context of networks defined by the static topology of enzyme-metabolite interactions and by the reaction fluxes that are feasible at steady state. We use the local topology and the flux correlations to identify...
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