Molecular evolution in light of regulatory-coding epistasis.

Abstract excerpt

Predicting the fitness effects of mutations is central to understanding molecular evolution and interpreting genome sequence data. Such predictions remain challenging due to the inter-dependent roles of coding and non-coding genetic variation. While coding mutations alter protein structure, stability, activity, and sometimes abundance, regulatory mutations modulate gene expression timing and levels. Because...

Topics

• Epistasis, Genetic
• Evolution, Molecular
• Genetic Fitness
• Mutation
• Animals
• Humans
• Phenotype