Article
Quantitative epistasis analysis and pathway inference from genetic interaction data.
PLoS computational biology - 1 May 2011
Phenix Hilary, Morin Katy, Batenchuk Cory, Parker Jacob, Abedi Vida, Yang Liu, Tepliakova Lioudmila, Perkins Theodore J, Kærn Mads
Abstract excerpt
Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an external signal. The model provides the basis of an experimental method to determine the architecture of such pathways, and establishes a new set of rules to infer the order...
Topics
- Computational Biology
- Epistasis, Genetic
- Galactose
- Gene Deletion
- Gene Expression Regulation, Fungal
- Gene Regulatory Networks
- Genes, Fungal
- Metabolic Networks and Pathways
- Models, Genetic
- Phenotype