Article
Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation
2019-01-31
Abstract excerpt
Brain metastases are prevalent in various types of cancer, and are often terminal given low efficacy of available therapies. Therefore, preventing them is of outmost clinical relevance and prophylactic treatments are perhaps the most efficient strategy. Here, we show that systemic prophylactic administration of a TLR9 agonist, CpG-C, is effective against brain metastases. Acute and chronic systemic administration...
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Identifiers and source
- Literature Corpus work
- f876b7aa-7a71-5c3f-9b40-1b650b523c4a
- DOI
- 10.1101/533927