Article

The CD8 <sup>+</sup> T cell landscape of human brain metastases

2021-08-05

Abstract excerpt

Despite improved outcomes with checkpoint blockade immunotherapy, patients with brain metastases have the worst prognosis among patients with metastatic cancer. Immune checkpoint blockade agents target inhibitory receptors, such as PD-1, on exhausted CD8 + T cells to restore their anti-cancer function. Many patients, however, either do not respond or progress after an initial response to immune checkpoint blockad...

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Identifiers and source

Literature Corpus work: 1fedf407-655a-52b3-be30-f4c62489f34e
DOI: 10.1101/2021.08.03.455000

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