Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10.

Cell - 25 Nov 2020

Guldner Ian H, Wang Qingfei, Yang Lin, Golomb Samantha M, Zhao Zhuo, Lopez Jacqueline A, Brunory Abigail, Howe Erin N, Zhang Yizhe, Palakurthi Bhavana, Barron Martin, Gao Hongyu, Xuei Xiaoling, Liu Yunlong, Li Jun, Chen Danny Z, Landreth Gary E, Zhang Siyuan

Abstract excerpt

Brain metastasis (br-met) develops in an immunologically unique br-met niche. Central nervous system-native myeloid cells (CNS-myeloids) and bone-marrow-derived myeloid cells (BMDMs) cooperatively regulate brain immunity. The phenotypic heterogeneity and specific roles of these myeloid subsets in shaping the br-met niche to regulate br-met outgrowth have not been fully revealed. Applying multimodal single-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL10

Share to CX3C Chemokine Receptor 1

Share to Immunosuppression Therapy

Share to Interferons

Share to Myeloid Cells

Share to Neutralization Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 33113353
DOI: 10.1016/j.cell.2020.09.064
PMCID: PMC7704908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10.PMID 33113353Read ↗

Cellular architecture of human brain metastases.Semantic proximity Read ↗

The CD8 <sup>+</sup> T cell landscape of human brain metastasesSemantic proximity Read ↗

Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8 <sup>+</sup> T cells in a NOS-dependent mannerSemantic proximity Read ↗

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencingSemantic proximity Read ↗

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2 <sup>+</sup> myeloid cells into the tumor microenvironment in a redundant mannerSemantic proximity Read ↗

Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastasesSemantic proximity Read ↗

Phenotypic diversity of T cells in human primary and metastatic brain tumors revealed by multiomic interrogationSemantic proximity Read ↗

Single-cell sequencing reveals the landscape of the human brain metastatic microenvironmentSemantic proximity Read ↗

Lineage and Spatial Mapping of Glioblastoma-associated ImmunitySemantic proximity Read ↗

Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain MetastasisSemantic proximity Read ↗

Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastasesSemantic proximity Read ↗

S100A9-Dependent CXCR2 <sup>hi</sup> Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.