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Article

NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment

24 Jun 2023

Abstract excerpt

Objective This study examined whether cerebrospinal fluid (CSF) baseline levels of the synaptic protein NPTX2 predict time to onset of symptoms of mild cognitive impairment (MCI), both alone and when accounting for traditional CSF Alzheimer's disease (AD) biomarker levels. Longitudinal NPTX2 levels were also examined. Methods CSF was collected longitudinally from 269 cognitively normal BIOCARD Study participants...

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PMID: 37345460
DOI: 10.1002/ana.26725

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