Article

TAK1 operates at the primary cilium in non-canonical TGFB/BMP signaling to control heart development

2024-05-08

Abstract excerpt

<h4>Summary</h4> Transforming Growth Factor-Beta-Activated Kinase 1 (TAK1/MAP3K7), along with its upstream regulators TAK1-Binding Protein 2 (TAB2) and the catalytic alpha-subunit of Protein Kinase A (PKA-Cα/PRKACA), has been identified as a pivotal player in regulation of developmental processes. Haploinsufficiency of TAB2 causes Congenital Heart Disease (CHD) and rare variants in PKA-Cα and TAK1 cause cardioacr...

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Literature Corpus work: 1f7f7d79-30c9-56d8-941c-6ee8cdb5f7be
DOI: 10.1101/2024.05.06.592628

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