Article

<i>alms1</i> regulates the immune response and brain ageing in zebrafish

2025-04-21

Abstract excerpt

<h4>ABSTRACT</h4> The ALMS1 gene plays a crucial role in maintaining cellular homeostasis through its involvement in primary cilium assembly, cytoskeletal regulation, and signalling pathways such as NOTCH and TGF-β. Pathogenic variants in ALMS1 are associated with Alström Syndrome (ALMS), a multi-systemic ciliopathy characterised by neurosensory deficits, metabolic disorders, and multi-organ fibrosis. To better...

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Literature Corpus work: 2bafd8b4-e190-5fca-9bc4-312ee090de49
DOI: 10.1101/2025.04.19.639742

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