Article
Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG).
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2022
Tayeh Marwan K, Gaedigk Andrea, Goetz Matthew P, Klein Teri E, Lyon Elaine, McMillin Gwendolyn A, Rentas Stefan, Shinawi Marwan, Pratt Victoria M, Scott Stuart A
Abstract excerpt
Pharmacogenomic testing interrogates germline sequence variants implicated in interindividual drug response variability to infer a drug response phenotype and to guide medication management for certain drugs. Specifically, discrete aspects of pharmacokinetics, such as drug metabolism, and pharmacodynamics, as well as drug sensitivity, can be predicted by genes that code for proteins involved in these pathways....
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