Article

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

2020-11-23

Abstract excerpt

Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization (MR) analyses, deriving genetic instruments based on transcriptomic and proteomic data for 1,263 actionable proteins that are targeted by approved drugs or in clinical phase of drug development. Using summary statistics f...

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Literature Corpus work: 7b074900-8a16-5530-9b3c-7c0b5def54fc
DOI: 10.1101/2020.11.19.20234120

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