Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Genomics and Drug Development.

Cold Spring Harbor perspectives in medicine - 1 Feb 2022

Schmidt Amand F, Hingorani Aroon D, Finan Chris

Abstract excerpt

Insights into the genetic basis of human disease are helping to address some of the key challenges in new drug development including the very high rates of failure. Here we review the recent history of an emerging, genomics-assisted approach to pharmaceutical research and development, and its relationship to Mendelian randomization (MR), a well-established analytical approach to causal inference. We demonstrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Development
Share to Genome, Human
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 34649961
DOI: 10.1101/cshperspect.a039230
PMCID: PMC8805642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Genomics and Drug Development.PMID 34649961Read ↗

Flipping the odds of drug development success through human genomicsSemantic proximity Read ↗

The support of human genetic evidence for approved drug indications.Semantic proximity Read ↗

A genomic-led strategy to anticipate drug safety effects.Semantic proximity Read ↗

Mendelian randomization for studying the effects of perturbing drug targetsSemantic proximity Read ↗

A genomic-led strategy to anticipate drug safety effectsSemantic proximity Read ↗

Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.Semantic proximity Read ↗

The druggable genome and support for target identification and validation in drug developmentSemantic proximity Read ↗

Target Discovery for Drug Development Using Mendelian Randomization.Semantic proximity Read ↗

Human genetic evidence enriched for side effects of approved drugsSemantic proximity Read ↗

Future prospects for human genetics and genomics in drug discovery.Semantic proximity Read ↗

Human genetics as a foundation for innovative drug developmentSemantic proximity Read ↗

Genetics in drug discovery and development: challenge and promise of individualizing treatment in common complex diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.