Article

Genetic dose-response modelling predicts drug mechanisms, dosing, and adverse events

2026-07-06

Abstract excerpt

Understanding how changes in gene function affect disease risk is central to drug development. Genetic variants are natural perturbations of gene activity and provide an opportunity to systematically model dose-response relationships between genes and phenotypes. Here, we present Variant-Informed Dose-Response Analysis (VIDRA), a computational framework that integrates trait-associated variants spanning a spectrum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6b45a0c-e996-5245-9f73-ea4b774a1bdd
DOI: 10.64898/2026.07.04.26357214

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic dose-response modelling predicts drug mechanisms, dosing, and adverse eventsDOI 10.64898/2026.07.04.26357214Read

A genomic-led strategy to anticipate drug safety effectsSemantic proximity Read

Characterizing the genetic architecture of drug response using gene-context interaction methods.Semantic proximity Read

Relating human genetic variation to variation in drug responses.Semantic proximity Read

A genomic-led strategy to anticipate drug safety effects.Semantic proximity Read

The genome as pharmacopeia: association of genetic dose with phenotypic response.Semantic proximity Read

Genetically supported drug target prioritization for rare diseases.Semantic proximity Read

Characterizing the genetic architecture of drug response using gene-context interaction methodsSemantic proximity Read

Insights from genome-wide association studies of drug response.Semantic proximity Read

Theoretical basis for the identification of allelic variants that encode drug efficacy and toxicity.Semantic proximity Read

Compilation of a comprehensive gene panel for systematic assessment of genes that govern an individual's drug responses.Semantic proximity Read

Drug Response Pharmacogenetics for 200,000 UK Biobank Participants.Semantic proximity Read

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traitsSemantic proximity Read