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Acute Myeloid Leukemia Stem Cells: The Challenges of Phenotypic Heterogeneity

12 Dec 2020

Abstract excerpt

Patients suffering from acute myeloid leukemia (AML) show highly heterogeneous clinical outcomes. Next to variabilities in patient-specific parameters influencing treatment decisions and outcome, this is due to differences in AML biology. In fact, different genetic drivers may transform variable cells of origin and co-exist with additional genetic lesions (e.g., as observed in clonal hematopoiesis) in a variety...

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PMID: 33322769
DOI: 10.3390/cancers12123742

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