Article

Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing

2024-06-13

Abstract excerpt

We present an efficient approach for synthesizing cationic poly(ethylene imine) derivatives using the multicomponent split-Ugi reaction to rapidly create a library of complex functional ionizable lipopolymers. We synthesized a diverse library of 155 polymers, formulated them into polyplexes to establish structure-activity relationships crucial for endosomal escape and efficient transfection. After discovering a le...

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Literature Corpus work: f83a5e42-e250-5ec9-b1ff-19f1455218b4
DOI: 10.1101/2024.06.11.598497

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