Article

Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing <i>in vivo</i>

2025-03-01

Abstract excerpt

mRNA-based gene editing therapeutics offer the potential to permanently cure diseases but are hindered by suboptimal delivery platforms. Here, we devise a robust combinatorial chemistry for plug-and-play assembly of diverse biodegradable ionizable lipids and identify a lead candidate that produces superior lipid nanoparticles for various gene editing tools delivery in vivo . Our study highlights the utility of th...

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Identifiers and source

Literature Corpus work: 457e2976-0045-57e6-b1f6-da679adcd771
DOI: 10.1101/2025.02.25.640222

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