Article

Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types

2024-12-02

Abstract excerpt

Efficient delivery of the CRISPR/Cas9 system and its larger derivatives, base editors, and prime editors remain a significant challenge, particularly in tissue-specific stem cells and induced pluripotent stem cells (iPSCs). This study optimized a novel family of cell-penetrating peptides, hPep, to deliver gene-editing ribonucleoproteins. The hPep-based nanoparticles enable highly efficient and biocompatible delive...

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Literature Corpus work: f17ed7fa-731e-5fd3-878b-f6b06e307679
DOI: 10.1101/2024.11.27.624305

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