An exosome-based gene delivery platform for cell-specific CRISPR/Cas9 genome editing

Abstract excerpt

<h4>ABSTRACT</h4> Exosomes are naturally occurring vesicles that have the potential to be manipulated to become promising drug delivery vehicles for on-demand in vitro and in vivo gene editing. Here, we developed the modular safeEXO platform, a prototype exosome delivery vehicle that is mostly devoid of endogenous RNA and can efficaciously deliver RNA and ribonucleoprotein (RNP) complexes to their intended intrac...

Topics

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• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Extracellular Vesicles
• Extracellular vesicles in disease
• Gene Editing
• Gene Transfer Techniques
• Mutation
• RNA

Identifiers and source

Literature Corpus work

6ed86fe2-1e75-521b-9531-72a9cd8dc11d

DOI

10.1101/2023.06.09.542202