Article

Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells

2024-06-03

Abstract excerpt

<title>Abstract</title> Mutations in RNA splicing factor genes including SF3B1, U2AF1, SRSF2, and ZRSR2 have been reported to contribute to development of myeloid neoplasms including myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML). Chemical tools targeting cells carrying these mutant genes remain limited and underdeveloped. Among the four proteins, mutant U2AF1 (U2AF1mut)...

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Literature Corpus work: f83487b0-4f05-5351-9d27-93b82e2eb8a7
DOI: 10.21203/rs.3.rs-4477663/v1

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