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Article

U2AF1 mutations alter splice site recognition in hematological malignancies.

Genome research - 1 Jan 2015

Ilagan Janine O, Ramakrishnan Aravind, Hayes Brian, Murphy Michele E, Zebari Ahmad S, Bradley Philip, Bradley Robert K

Abstract excerpt

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 alter its normal role in RNA splicing. We find that U2AF1 mutations influence the similarity of splicing programs in leukemias, but do not give rise to...

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Source

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Identifiers

PMID: 25267526
DOI: 10.1101/gr.181016.114
PMCID: PMC4317169

Genes

ATR
CASP8
FANCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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