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Article

Identification of a small molecule splicing inhibitor targeting UHM domains.

The FEBS journal - 1 Feb 2022

Kobayashi Asaki, Clément Marie-Jeanne, Craveur Pierrick, El Hage Krystel, Salone Jean de Matha, Bollot Guillaume, Pastré David, Maucuer Alexandre

Abstract excerpt

Splicing factor mutations are frequent in myeloid neoplasms, blood cancers, and solid tumors. Cancer cells harboring these mutations present a particular vulnerability to drugs that target splicing factors such as SF3b155 or CAPERα. Still, the arsenal of chemical probes that target the spliceosome is very limited. U2AF homology motifs (UHMs) are common protein interaction domains among splicing factors. They...

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Identifiers

PMID: 34520118
DOI: 10.1111/febs.16199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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