Article

Crucial Aspects for Maintaining rAAV Stability

2024-07-30

Abstract excerpt

<title>Abstract</title> <p>Background The storage of rAAV vectors for gene therapy applications is critical for ensuring a constant product quality and defined amount of medication at the time of administration. Therefore, we determined the influence of different storage conditions on the physicochemical and biological properties of rAAV8 and rAAV9 preparations. Particular attention was paid to short-term storag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f82cd01f-a25f-53d9-8dcc-626e2f87c953
DOI: 10.21203/rs.3.rs-4685335/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Crucial Aspects for Maintaining rAAV StabilityDOI 10.21203/rs.3.rs-4685335/v1Read

Development of Long-Term Stability of Enveloped rVSV Viral Vector Expressing SARS-CoV-2 Antigen Using a DOE-Guided ApproachSemantic proximity Read

Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidateSemantic proximity Read

Characterizing the Biopotency of Truncated Transgene Variants in rAAV8 viral vectors: Essential Considerations for Gene Therapy ApplicationsSemantic proximity Read

Methods Matter -- Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct VectorsSemantic proximity Read

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapiesSemantic proximity Read

Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturingSemantic proximity Read

Recent Advances in the Analysis Full/Empty Capsid Ratio and Genome Integrity of Adeno-associated Virus (AAV) Gene Delivery VectorsSemantic proximity Read

Removal of Empty Capsids from High-Dose Adeno-Associated Virus 9 Gene TherapiesSemantic proximity Read

The Role of Thermal Stability in AAV Titration of Engineered VariantsSemantic proximity Read

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV ManufacturingSemantic proximity Read

Heat Stable and Intrinsically Sterile Liquid Protein FormulationsSemantic proximity Read

AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations.Semantic proximity Read