Article

Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate

2023-03-13

Abstract excerpt

Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s physicochemical properties and biological potency. To this end, we evaluated an rAAV-based COVID-19 vaccine candidate which encodes the Spike antigen (AC3) and is produc...

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Literature Corpus work: 78b2984b-7bce-51db-86a6-2c719965a376
DOI: 10.1101/2023.03.10.532114

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