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Article

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

17 Feb 2021

Abstract excerpt

The optimization of upstream and downstream processes for production of recombinant adeno-associated virus (rAAV) with consistent quality depends on the ability to rapidly characterize critical quality attributes (CQAs). In the context of rAAV production, the virus titer, capsid content, and aggregation are identified as potential CQAs, affecting the potency, purity, and safety of rAAV-mediated gene therapy...

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PMID: 33738328
DOI: 10.1016/j.omtm.2021.02.010

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