Article

Heat Stable and Intrinsically Sterile Liquid Protein Formulations

2024-02-22

Abstract excerpt

Over 80% of biologic drugs, and 90% of vaccines, require temperature-controlled conditions throughout the supply chain to minimize thermal inactivation and contamination. This cold chain is costly, requires stringent oversight, and is impractical in remote environments. Here, we report chemical dispersants that non-covalently solvate proteins within fluorous liquids to alter their thermodynamic equilibrium and red...

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Identifiers and source

Literature Corpus work: 91017853-1529-5270-9f12-91d9e1a4f8de
DOI: 10.1101/2024.02.19.581015

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