Article
AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations.
Molecular therapy : the journal of the American Society of Gene Therapy - 7 Jun 2017
Pacouret Simon, Bouzelha Mohammed, Shelke Rajani, Andres-Mateos Eva, Xiao Ru, Maurer Anna, Mevel Mathieu, Turunen Heikki, Barungi Trisha, Penaud-Budloo Magalie, Broucque Frédéric, Blouin Véronique, Moullier Philippe, Ayuso Eduard, Vandenberghe Luk H
Abstract excerpt
Adeno-associated virus (AAV) vectors are promising clinical candidates for therapeutic gene transfer, and a number of AAV-based drugs may emerge on the market over the coming years. To insure the consistency in efficacy and safety of any drug vial that reaches the patient, regulatory agencies require extensive characterization of the final product. Identity is a key characteristic of a therapeutic product, as it...
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